Current Strategies in Cancer Gene Therapy by Wolfgang Walther

Author:Wolfgang Walther
Language: eng
Format: epub
Publisher: Springer International Publishing, Cham

Integration

DNA vaccines are able to integrate into the host genome, which might result in insertional mutagenesis and chromosomal instability

RNA cannot integrate into the genome and therefore has no oncogenic potential

Expression

Long-term expression possible (months to years), depending on vector

Transient expression

Hence, RNActive® vaccines are containing two components that serve complementary functions: “naked” mRNA, which serves as a translation template responsible for strong expression of the encoded antigen, and mRNA–protamine complexes, which enhance the immune stimulatory capacity of the vaccine. Indeed, vaccination with RNActive® vaccines has been shown to induce strong and balanced immune responses, i.e., Th1 and Th2, humoral and cellular, and effector and memory responses. Encouraging results have been gained in various animal model systems, among others mice, ferrets, and pigs, both in the field of cancer immunotherapy (Fotin-Mleczek et al. 2011, 2012) and prophylactic vaccines (Petsch et al. 2012; Kowalczyk et al. 2016; Schnee et al. 2016).

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